Typically patch bays are set up to follow signal flow, with instruments/sources on the left, then computer I/O, then effects/processors. When it’s your patchbay though, you can of course lay it out however you like.
Re: Normalling/Halfnormalling: There’s kind of no reason to use full normal. If you really want to block stuff going through you can put a patch cable in and just let it dangle to cut the input. If, for example, you want to run your stereo mix into your PCM recorder/reel-to-reel/archival device and listen on your monitors to the computer output you’ll wish you had it set up half-normal.
I might also just hardwire the monitors to the interface and skip the patchbay for that part as you’re going to invite some nasty pops and cracks as you plug/unplug stuff there. There’s other stuff that you might be able to do there but I don’t know the I/O capabilities of your AD/DA converter.
I absolutely would have as many outputs and inputs on the patchbay as possible because that’s how you’ll engage and route the signal to your analog hardware. It’s why you have a patchbay in the first place.
If you have routings you use regularly (i.e. normally), set your patchbay up to take advantage of that with half-normalling. Even if that means “misaligning” the gear in the patchbay.
For example, if you always record in with a Prophet and OB6 go ahead and set them up to half-normal into your interface inputs. Or if you always run part of your mix through the Valley People (I know I would if I had one) then go ahead and half-normal some interface outs to the In of the Valley People. And I’d do this for full chains as well, so if you always go from the Prophet to the Gatex to the computer then I would line up the patchbay signal path with half-normals so it doesn’t require any patch cables.
If it was me laying this out, I’d put the synths on the left out row, half-normalled into the interface ins on the left ins row. Then I’d run the interface outs on the out row half-normalled into the whatever their usual things were (looks like maybe you have some key inputs or something, I’m not familiar with the Gatex or DS201). Last I’d put any fun gear that isn’t usually patched with their outs above their ins and isolated/de-normalled/“through”.